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Fig. 3 | Respiratory Research

Fig. 3

From: Role of Secretoglobin+ (club cell) NFκB/RelA-TGFβ signaling in aero-allergen-induced epithelial plasticity and subepithelial myofibroblast transdifferentiation

Fig. 3

Mucosal TGFβ signaling is regulated by IKK. C57BL/6 J mice were treated with daily challenges of CDE or PBS i.n. and given BMS-345541 (IKKi) i.p. simultaneously over 5 days, n = 5–6. A IFM. Sections were stained with anti p-SMAD3 Ab (red) and DAPI (blue). Representative images shown at × 20 magnification, with selected enhanced image of the epithelium. B Quantitation of p-SMAD3. Relative fold changes in FI for each treatment group. C mRNA abundance. Relative fold changes in RelA and Tgfβ1 mRNA abundance in total lung by Q-RT-PCR. D Changes in mesenchymal gene expression. Relative fold changes in Snai1, Zeb1, and Vim mRNAs in total lung RNA; *p < 0.05 compared to Control, t-test

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