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Fig. 1 | Respiratory Research

Fig. 1

From: TRB3 mediates vascular remodeling by activating the MAPK signaling pathway in hypoxic pulmonary hypertension

Fig. 1

The expression of TRB3 was regulated by hypoxia and ERS. A A heat map of the hierarchical clustering of gene expression profiling of rat PASMCs for ERS from the Agilent Whole Rat Genome Oligo Microarrays. Each gene is depicted by one row, in which the red color denotes an increase in gene expression and the green color denotes a decrease in gene expression compared to the other group. Brighter colors represent higher gene expression levels. B TRB3 protein expression in PASMCs treated with hypoxia for different times. C The rats in the hypoxia group were exposed to 10% O2 for 8 h a day, and after 4 weeks, lung tissues were stained with hematoxylin–eosin (HE). D TRB3 protein expression in lung tissues and pulmonary arteries. E–G TRB3 protein expression in PASMCs treated with 4-PBA, TG, and 4μ8C. Data represent the mean ± SEM (n = 4). *P < 0.05 and **P < 0.01 compared to the group exposed to hypoxia for 0 h. #P < 0.05 and ##P < 0.01 compared to PASMCs exposed to hypoxia for 48 h

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