Table 1 Baseline characteristics between non-awake ECMO and awake ECMO patients
Non-awake ECMO (n = 39) | Awake ECMO (n = 25) | p | |
|---|---|---|---|
Age, years | 55 (49–62) | 59 (52.5–63) | 0.608 |
Male, sex | 21 (53.8) | 20 (80) | 0.033 |
Donor age, years | 45 (35–54.5) | 43 (33–53) | 0.650 |
Donor, male, sex | 27 (69.2) | 11 (44.0) | 0.045 |
BMI, kg/m2 | 22.0 (19.0–25.3) | 19.3 (16.8–23.2) | 0.124 |
Primary lung disease | 0.302 | ||
IPF | 17 (43.6) | 14 (56) | |
AIP/ARDS | 4 (10.3) | 0 (0) | |
CTD-related ILD | 7 (17.9) | 4 (16) | |
BO after PBSCT | 1 (2.6) | 2 (8) | |
Other | 10 (25.7) | 5 (20) | |
Hypertension | 10 (25.6) | 5 (20) | 0.603 |
Diabetes mellitus | 13 (33.3) | 6 (24) | 0.425 |
Pulmonary hypertension | 22 (56.4) | 12 (48) | 0.511 |
Waiting list time, daysª | 14 (8–63.5) | 87 (44–213) | 0.001 |
TTE parameters before LTx | |||
EF, % | 61 (56–68) | 62 (55–68) | 1 |
E/E’ | 10.4 (8–12) | 10 (8.2–12) | 0.75 |
RVSP, mmHg | 50 (30.8–64) | 49 (37.5–53) | 0.919 |
TAPSE, cm | 1.9 (1.3–4.7) | 1.8 (1.3–12) | 1 |
TDI | 12 (9–13) | 11 (8.1–13.3) | 0.647 |
APACHE II score | 22 (18–28) | 18 (13–19) | 0.005 |
ECMO blood flow, mL | 3170 (2880–3550) | 3010 (2525–3575) | 0.608 |
ECMO duration, days | 12 (5–20) | 13 (8–17) | 0.841 |
ECMO configuration | 0.250 | ||
VV (jugular-femoral), % | 37 (94.9) | 25 (100) | |
VA (femoral-femoral), % | 2 (5.1) | 0 (0) | |
Type of transplantation | 0.420 | ||
Bilateral transplantation,% | 38 (97.4) | 25 (100) | |
Single transplantation, % | 1 (2.6) | 0 (0) | |
Ischemia time, s | 205 (190.5–274.0) | 230 (192–265) | 0.680 |
Post-transplant TTE parameters | |||
EF, % | 62 (58–68) | 65 (62–69.5) | 0.257 |
E/E’ | 11 (6.5–11.5) | 9.5 (7–12.8) | 0.289 |
RVSP, mmHg | 27 (25–38) | 34.5 (28.5–39) | 0.55 |
Ventilator free days | 0 (0–15) | 24 (17–26) | < 0.001 |
Ability to gait after LTx | 23 (59) | 23 (92) | 0.004 |
Time to gaiting, days | 27.5 (18.5–37.5) | 17 (10.0–29) | 0.042 |
Three-months mortality | 9 (23.1) | 1 (4) | 0.074 |
Six-month mortality | 15 (38.5) | 3 (12) | 0.022 |
One-year mortality | 21 (53.8) | 6 (24) | 0.018 |
ICU length of stay, days | 18 (11–36) | 6 (4–8.5) | < 0.001 |
Hospital length of stay, days | 61 (39–107) | 36 (24–91) | 0.061 |
Six-month FVC, % (14/18)* | 62 (50.5–67.8) | 70 (59.5–78.5) | 0.059 |
Six-month FEV1, % (14/18)* | 61 (41.5–73.3) | 77.5 (69–96.5) | 0.004 |
One-year FVC, % (15/18)* | 63 (53–69) | 71 (62.8–79.3) | 0.04 |
One-year FEV1, % (15/18)* | 57 (49–70) | 75 (61.5–96.8) | 0.013 |