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Table 4 Association between sex and primary and secondary outcomes: Overlap propensity score-weighted average treatment effect among the overlap population (ATO)

From: Analysis of sex-based differences in clinical and molecular responses to ischemia reperfusion after lung transplantation

 

ATO (95% CI)

p value

Primary outcomes

 PGD3 at T48

− 0.143 (− 0.290, − 0.028)

0.055

 PGD3 at T72

− 0.065 (− 0.204, 0.075)

0.365

 PGD decrease from T0 to T72

0.193 (0.048, 0.337)

0.009

 PGD difference from T72 to T0

− 0.319 (− 0.631, − 0.007)

0.045

Secondary outcomes

 Postoperative bacteremia

0.072 (− 0.063, 0.207)

0.295

 Postoperative wound infection

0.020 (− 0.054, 0.094)

0.601

 C. difficile colitis

0.055 (− 0.014, 0.124)

0.119

 90-d survival

0.042 (− 0.017, 0.100)

0.164

 1-y survival

0.040 (− 0.093, 0.172)

0.555

 Peak lactate within 72 h, mg/dL

− 1.565 (− 2.622, − 0.509)

0.004

 Stroke

0.007 (− 0.066, 0.080)

0.854

 Acute rejection during hospitalization

− 0.052 (− 0.162, 0.059)

0.362

 ICU LOS, d

3.249 (− 4.766, 11.263)

0.427

 Tracheostomy

0.126 (− 0.013, 0.265)

0.075

 Airway dehiscence

− 0.012 (− 0.072, 0.049)

0.703

 Mechanical ventilation ≥ 5 d

0.130 (− 0.010, 0.270)

0.069

 Postoperative ECMO

− 0.038 (− 0.149, 0.074)

0.507

 Readmission within 1 y

− 0.029 (− 0.140, 0.082)

0.607

  1. Data reported as ATO (95% CI). 95% CI not including 0 indicates a statistically significant difference in secondary outcome between men and women
  2. ECMO extracorporeal membrane oxygenation, ICU intensive care unit, LOS length of stay, PGD primary graft dysfunction