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Table 1 The results of epigenome-wide association study in pulmonary function (P-value < 1 × 10–4)

From: Genome-wide DNA methylation analysis of pulmonary function in middle and old-aged Chinese monozygotic twins

Chromosome

Position(bp)

Coefficient

P-value

Ensemble gene ID

HGNC symbol

FEV1

     

 chr3

138,639,540

 − 1.93791

1.81E−05

  

 chr3

138,639,552

 − 1.94154

1.87E−05

  

 chr3

138,639,544

 − 1.9364

1.9E−05

  

 chr3

138,639,520

 − 1.92289

2.26E−05

  

 chr6

43,394,632

 − 1.49082

2.87E−05

  

 chr6

43,394,620

 − 1.48934

2.9E−05

  

 chr16

706,133

0.287479

3.29E−05

ENSG00000161996

WDR90

 chr14

104,008,425

 − 1.59238

4.23E−05

  

 chr6

43,394,652

 − 1.47384

4.29E−05

  

 chr6

43,394,599

 − 1.56562

4.39E−05

  

 chr17

40,997,066

 − 0.79359

4.44E−05

ENSG00000131480

AOC2

 chr14

104,008,420

 − 1.19154

4.65E−05

  

 chr10

527,775

 − 1.12976

4.89E−05

ENSG00000151240

DIP2C

 chr19*

45,721,153

 − 0.40397

5.27E−05

ENSG00000130201

EXOC3L2

    

ENSG00000007047

MARK4

 chr19

48,945,113

 − 1.67386

5.63E−05

ENSG00000105464

GRIN2D

 chr19*

45,721,139

 − 0.36067

6.24E−05

ENSG00000130201

EXOC3L2

    

ENSG00000007047

MARK4

 chr22

50,616,743

2.576796

6.52E−05

ENSG00000073150

PANX2

 chr12

132,922,443

 − 0.85158

6.6E−05

  

 chr13

114,322,962

 − 1.33518

6.9E−05

ENSG00000185974

GRK1

 chr22

50,616,740

2.562951

6.92E−05

ENSG00000073150

PANX2

 chr19

48,945,126

 − 1.64199

7.32E−05

ENSG00000105464

GRIN2D

 chr22

50,616,733

2.538738

7.84E−05

ENSG00000073150

PANX2

 chr19

48,945,131

 − 1.63696

8.05E−05

ENSG00000105464

GRIN2D

 chr16*

1,835,849

 − 1.47921

8.48E−05

ENSG00000095906

NUBP2

    

ENSG00000162032

SPSB3

 chr6

41,207,271

0.322382

9.19E−05

ENSG00000212176

RNA5SP207

FVC

     

 chr2

227,662,476

2.083124

4.88E−06

ENSG00000169047

IRS1

 chr2

227,662,482

2.066378

5.49E−06

ENSG00000169047

IRS1

 chr2

227,662,501

2.013397

6.8E−06

ENSG00000169047

IRS1

 chr1

3,329,105

0.283266

9.86E−06

ENSG00000142611

PRDM16

 chr2

242,955,278

 − 3.46707

1.22E−05

ENSG00000233806

LINC01237

 chr7

56,243,280

 − 0.31459

1.51E−05

  

 chr1

40,388,312

0.248359

1.64E−05

  

 chr1

34,090,712

0.342628

1.72E−05

ENSG00000121904

CSMD2

 chr2

227,662,462

1.963614

1.82E−05

ENSG00000169047

IRS1

 chr9

34,809,867

 − 0.32198

1.94E−05

  

 chr1

212,456,833

 − 1.22998

2E−05

ENSG00000226251

LINC02608

 chr2

227,662,459

1.962235

2.04E−05

ENSG00000169047

IRS1

 chr1

34,090,722

0.360194

2.13E−05

ENSG00000121904

CSMD2

 chr1

40,388,299

0.247353

2.44E−05

  

 chr4

39,719,509

 − 0.33384

2.57E−05

ENSG00000078140

UBE2K

 chr4

39,719,504

 − 0.33124

2.65E−05

ENSG00000078140

UBE2K

 chr1

45,203,996

0.682629

2.67E−05

  

 chr11

65,547,072

 − 0.2697

2.84E−05

ENSG00000254470

AP5B1

 chr2

227,662,443

1.966677

3.2E−05

ENSG00000169047

IRS1

 chr19

55,881,590

1.590547

3.51E−05

ENSG00000095752

IL11

 chr2

227,662,433

1.985295

3.55E−05

ENSG00000169047

IRS1

 chr2

227,662,426

2.006028

3.6E−05

ENSG00000185950

IRS2

 chr14

94,405,044

 − 0.85692

3.86E−05

ENSG00000100628

ASB2

 chr17

79,067,393

2.782969

3.97E−05

ENSG00000175866

BAIAP2

 chr19

55,881,582

1.540431

4.08E−05

ENSG00000095752

IL11

 chr7

56,243,259

 − 0.2817

4.14E−05

  

 chr9

34,809,843

 − 0.27944

4.38E−05

  

 chr17

75,613,156

0.367264

4.43E−05

  

 chr16

2,301,960

 − 1.99883

4.49E−05

ENSG00000167969

ECI1

 chr5

179,554,467

0.172032

5.14E−05

ENSG00000146090

RASGEF1C

 chr9

34,809,878

 − 0.33026

5.28E−05

  

 chr17

75,613,186

0.259034

5.33E−05

  

 chr12

106,461,103

 − 1.84659

5.55E−05

ENSG00000074590

NUAK1

 chr16

2,301,969

 − 1.97289

5.66E−05

ENSG00000167969

ECI1

 chr7

56,243,241

 − 0.27378

5.66E−05

  

 chr2

227,662,390

2.353652

5.79E−05

ENSG00000169047

IRS1

 chr5

179,554,462

0.167814

5.91E−05

ENSG00000146090

RASGEF1C

 chr7

56,243,233

 − 0.2686

5.96E−05

  

 chr13*

114,525,556

 − 2.57251

6.25E−05

ENSG00000183087

GAS6

    

ENSG00000233695

GAS6 − AS1

 chr5

179,554,486

0.182607

6.36E−05

ENSG00000146090

RASGEF1C

 chr2

72,359,706

0.217285

6.44E−05

ENSG00000003137

CYP26B1

 chr19

22,883,687

2.353067

7E−05

  

 chr1

40,388,332

0.260153

7.03E−05

  

 chr20

62,188,249

0.178865

7.56E−05

  

 chr19

22,883,684

2.335013

7.71E−05

  

 chr19

36,757,583

0.700594

7.8E−05

  

 chr20

62,188,262

0.179876

8.09E−05

  

 chr22

50,758,097

0.338362

8.16E−05

ENSG00000205593

DENND6B

 chr12

123,750,717

 − 0.26888

8.23E−05

ENSG00000111328

CDK2AP1

 chr7

2,106,405

 − 3.75532

8.27E−05

ENSG00000002822

MAD1L1

 chr7

56,243,224

 − 0.25655

8.39E−05

  

 chr4

39,719,480

 − 0.31037

8.63E−05

ENSG00000078140

UBE2K

 chr1

181,382,667

0.338413

8.9E−05

mRNA

AF387615

 chr4

39,719,523

 − 0.34507

9.3E−05

ENSG00000078140

UBE2K

 chr10

88,702,832

 − 1.01265

9.46E−05

ENSG00000173269

MMRN2

 chr2

72,359,687

0.201322

9.56E−05

ENSG00000003137

CYP26B1

 chr16

86,528,639

 − 1.92693605

2.2733E−06

ENSG00000268388

FENDRR

 chr11

89,900,493

 − 8.57710522

1.042E−05

ENSG00000077616

NAALAD2

 chr6

168,708,413

2.6198784

1.0891E−05

ENSG00000164488

DACT2

 chr11

89,900,518

 − 8.40993874

1.2848E−05

ENSG00000077616

NAALAD2

 chr16

86,528,603

 − 2.37934592

1.4343E−05

ENSG00000268388

FENDRR

 chr16

86,528,620

 − 2.56207502

1.4967E−05

ENSG00000268388

FENDRR

 chr2

233,791,733

2.516547

1.601E−05

ENSG00000066248

NGEF

 chr16

86,528,600

 − 2.29834345

1.6392E−05

ENSG00000268388

FENDRR

 chr6

168,708,422

2.86106788

1.7273E−05

ENSG00000164488

DACT2

 chr11

130,491,262

 − 3.95462385

2.2669E−05

  

 chr6

168,708,401

2.15447478

2.3564E−05

ENSG00000164488

DACT2

 chr2

233,791,742

2.27761208

3.1105E−05

ENSG00000066248

NGEF

 chr16

86,528,611

 − 2.78067202

3.1934E−05

ENSG00000268388

FENDRR

 chr11

130,491,234

 − 3.50377946

3.2327E−05

  

 chr11

130,491,229

 − 3.49295666

3.2607E−05

  

 chr11

130,491,225

 − 3.49165833

3.3003E−05

  

 chr11

130,491,218

 − 3.4800439

3.9356E−05

  

 chr11

130,491,274

 − 5.32113664

4.9746E−05

  

 chr20

61,992,129

8.76860666

5.2202E−05

ENSG00000101204

CHRNA4

 chr11

1,103,266

 − 1.68641265

5.3477E−05

ENSG00000198788

MUC2

 chr4

10,508,681

 − 3.48381736

5.411E−05

ENSG00000109684

CLNK

 chr11

130,491,277

 − 5.2862281

5.6835E−05

  

 chr8

6,671,626

 − 2.57808863

5.7509E−05

ENSG00000275591

XKR5

 chr1

7,022,170

8.69574765

5.8044E−05

ENSG00000171735

CAMTA1

 chr11

1,103,270

 − 1.68935565

5.9685E−05

ENSG00000198788

MUC2

 chr4

190,537,048

 − 3.24980484

7.2585E−05

  

 chr14

104,642,230

 − 4.53713759

7.4715E−05

ENSG00000066735

KIF26A

 chr4

190,537,044

 − 3.22472764

7.9082E−05

  

 chr5

28,928,500

 − 8.72472679

8.3633E−05

  

 chr16

86,528,570

 − 1.82984517

8.7526E−05

ENSG00000268388

FENDRR

 chr22

29,075,315

11.8597904

9.15E−05

ENSG00000100154

TTC28

  1. *The CpG sites were annotated to more than one gene