Predictive value of chest HRCT for survival in idiopathic pulmonary arterial hypertension

Respiratory Research

Table 5 Predictors of outcome in the 2-year perspective

	DEATH or LTX In a 2-year perspective
	Univariate		Multivariate
	Hazard ratio (95% CI)	p-value	Hazard ratio (95% CI)	p-value
WHO FC 4	5.89 (1.64–21.19)	0.04
cGGO	5.01 (1.95–13.00)	0.0009	6.22 (1.37–28.18)	0.018
DLCO [%pred]	0.96 (0.93–0.99)	0.001	0.95 (0.92–0.98)	0.005
NT-proBNP [pg/ml]	1.0003 (1.0001–1.0004)	0.003
6MWT ΔSpO₂ [%point]	1.05 (0.999–1.1)	0.05	1.13 (1.04–1.22)	0.004

Bold values denote statistical significance at the p < 0.05 level
WHO FC, World Health Organisation functional class; cGGO, centrilobular ground glass opacifications; DLCO, diffusion lung capacity for carbon monoxide; NT-proBNP, N-terminal pro-brain natriuretic peptide; 6MWT ΔSpO₂, change of blood oxygen saturation during 6-min walking test

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