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Table 1 Demographic, functional and biochemical parameters for the whole group and according to the HRCT pattern

From: Predictive value of chest HRCT for survival in idiopathic pulmonary arterial hypertension

  All patients cGGO pattern pGGO pattern Normal pattern p value*
N Median (IQR) or N (%) N Median (IQR) or N (%) N Median (IQR) or N (%) N Median (IQR) or N (%)
Age [years] 110 44.3 (30.0–56.6) 24 32.1 (24.3–49.0) 26 44 (27–49.6) 60 46.8 (37.6–59.0) 0.064
Age < 40 years 110 44 (40) 24 15 (63) 26 12 (46) 60 17 (28) 0.012
Sex female:male 110 80:30 (73:27) 24 20:4 (83:17) 26 23:3 (88:12) 60 37:23 (62:38) 0.016
Ever-smokers 106 41 (39) 21 9 (43) 26 5 (19) 59 27 (46) 0.062
Positive history of haemoptysis 108 18 (16) 24 7 (29) 26 6 (23) 58 5 (9) 0.046
PFO 93 29 (31) 22 7 (32) 20 8 (40) 59 14 (27) 0.59
WHO FC: 107   24   26   57   0.14
 1   0   0   0   0  
 2   57 (53)   14 (58)   17 (65)   26 (46)  
 3   44 (41)   7 (29)   8 (31)   29 (51)  
 4   6 (6)   3 (13)   1 (4)   2 (4)  
DLCO [%pred] 84 66.8 (52.8–76.5) 15 58.7 (33.4–71.6) 21 70.6 (60.4–73.6) 48 66.7 (39.0–83.1) 0.27
6MWD [m] 105 396 (318–474) 21 436 (380–484) 26 415.5 (380–484) 58 379.5 (298.0–450.0) 0.06
6MWD risk group: 105   21   26   58   0.34
 Low   37 (35)   10 (48)   11 (42)   16 (28)  
 Intermediate   63 (60)   11 (52)   14 (54)   38 (66)  
 High   5 (5)   0 (0)   1 (4)   4 (7)  
SpO2 [%] 105 86 (92–97) 21 96 (92–97) 26 96.5 (93–98) 58 95.0 (91.0–97.0) 0.20
6MWT ΔSpO2 102 5 (1–8) 21 5 (3–9) 26 4.5 (2–8) 55 4.0 (0.0–9.0) 0.50
NT-proBNP [pg/ml] 83 1079 (332–2592) 22 1619.5 (422.9–4331.0) 21 825 (219.9–1610.0) 40 1121.0 (360.0–2599.0) 0.30
NT-proBNP risk group: 83   22   21   40   0.54
 Low   18 (22)   4 (18)   6 (28.5)   8 (20)  
 Intermediate   29 (35)   6 (27)   9 (43)   14 (35)  
 High   36 (43)   12 (55)   6 (28.5)   18 (45)  
  1. Bold values denote statistical significance at the p < 0.05 level
  2. cGGO, centrilobular ground glass opacifications; pGGO, panlobular ground glass opacification; IQR, interquartile range; PFO, persistent foramen ovale; WHO FC, World Health Organisation functional class; DLCO, diffusion lung capacity for carbon monoxide; 6MWD, 6-min walking test distance; SpO2, blood oxygen saturation; NT, proBNP- N-terminal pro-brain natriuretic peptide. *For comparison between three HRCT patterns