Fig. 11

Effect of CYP2J2 overexpression and exogenous EETs on the expression of inflammation-related proteins. A Effect of CYP2J2 overexpression on inflammation-related proteins in rat lung tissues. The upper graph shows the representative Western blot plots of PPARγ, p-NF-κB p65 (Ser536), and t-NF-κB p65 in rat lung tissue of each group, and the lower graph shows the fold change of p-NF-κB p65/t-NF-κB p65 and PPARγ/GAPDH in each group to the relative density of Control group. Fold change was calculated by normalizing to control (fold change of control is 1). (n = 3; *P < 0.05 vs. Control, PAH or PAH + Sham group, ^#P < 0.05 vs. PAH + IR or PAH + IR + GFP group, ^$P < 0.05 vs. PAH + IR + 2J2 group). B Effect of exogenous EETs on inflammation-associated proteins in HPAECs. The upper graph shows the representative Western blot plots of PPARγ, p-NF-κB p65 (Ser536), and t-NF-κB p65 in each group of HPAECs, and the lower graph shows the fold change of p-NF-κB p65/t-NF-κB p65 and PPARγ/GAPDH in each group to the relative density of Control group. Fold change was calculated by normalizing to control (fold change of control is 1). (n = 3; *P < 0.05 vs. Control or TNF-α group, ^#P < 0.05 vs. TNF-α + AR or TNF-α + AR + DMSO group, ^$P < 0.05 vs. TNF-α + AR + EETs group)