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Fig. 4 | Respiratory Research

Fig. 4

From: Prostaglandin E2 sensitizes the cough reflex centrally via EP3 receptor-dependent activation of NaV 1.8 channels

Fig. 4

Effect of pretreatment with the EP1 antagonist, ONO-8130, on sulprostone-enhanced citric acid-induced cough. Pretreatment of guinea pigs with 15 μl of ONO-8130 (1 mg/ml; n = 7 and 5 mg/ml; n = 6, i.c.v.) did not affect the sulprostone-enhanced citric acid-induced cough response compared to vehicle (n = 10). Data are plotted as a scatter graph A and a bar chart B showing mean cough ± SEM

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