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Fig. 3 | Respiratory Research

Fig. 3

From: Prostaglandin E2 sensitizes the cough reflex centrally via EP3 receptor-dependent activation of NaV 1.8 channels

Fig. 3

Effect of treatment with the non-selective EP1/EP3 agonist, sulprostone, on citric acid-induced cough. Treatment of guinea pigs with 15 μl of sulprostone (0.1 mg/ml; n = 8, 0.3 mg/ml; n = 7 and 1 mg/ml; n = 9, i.c.v.) resulted in a dose-dependent increase in citric acid-induced cough response compared to vehicle (n = 9). Data are plotted as a scatter graph A and a bar chart B showing mean cough ± SEM. ** represents a statistically significant difference at P ≤ 0.01 when compared to vehicle treated animals

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Respiratory Research

ISSN: 1465-993X

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