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Fig. 2 | Respiratory Research

Fig. 2

From: Prostaglandin E2 sensitizes the cough reflex centrally via EP3 receptor-dependent activation of NaV 1.8 channels

Fig. 2

Effect of treatment with PGE2 on citric acid-induced cough. Treatment of guinea pigs with 15 μl of PGE2 (0.3 mg/ml; n = 8, 0.6 mg/ml; n = 12 and 1 mg/ml; n = 13, i.c.v.) resulted in a dose-dependent increase in citric acid-induced cough response compared to vehicle (n = 12). Data are plotted as a scatter graph A and a bar chart B, showing mean cough ± SEM. * and *** represent a statistically significant difference at P ≤ 0.05 and P ≤ 0.001, respectively, when compared to vehicle treated animals

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Respiratory Research

ISSN: 1465-993X

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