Fig. 10
Effect of pretreatment with a combination of JNJ-17203212 and HC-030031 on PGE2-enhanced citric acid-induced cough. Pretreatment of guinea pigs with a 15 μl of combination of TRPV1 antagonist JNJ-17203212 and TRPA1 antagonist, HC-030031 (Comb-L: 0.4 mg/ml and 0.02 mg/ml; n = 5 and Comb-H: 1.3 mg/ml and 0.05 mg/ml; n = 6, i.c.v.) did not affect the PGE2-enhanced citric acid-induced cough response compared to vehicle (n = 7). Data are plotted as a scatter graph A and a bar chart B showing mean cough ± SEM