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Fig. 5 | Respiratory Research

Fig. 5

From: Knockdown of circFOXO3 ameliorates cigarette smoke-induced lung injury in mice

Fig. 5

The miR-214-3p inhibitor attenuates the effects of circFOXO3 silencing thus upregulating IKK-β. A The effectiveness of miR-214-3p inhibition in MLE12 cells, judging from qRT-PCR data. B qRT-PCR analysis of IKK-β expression levels in circFOXO3 knockdown cells transfected with the miR-214-3p inhibitor followed by CSE treatment. C Western blotting analysis of the protein levels of IKK-β, p-IκBα, p-p65, p65, and GAPDH in the indicated cell groups. D Levels of CXCL1 and IL-6 in the culture supernatant were assessed by ELISAs. **P < 0.01 vs. Control group, ##P < 0.01 vs. NC/CSE group, &&P < 0.01 vs. circFOXO3/CSE group

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