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Fig. 2 | Respiratory Research

Fig. 2

From: Knockdown of circFOXO3 ameliorates cigarette smoke-induced lung injury in mice

Fig. 2

The knockdown of circFOXO3 prevented CS-induced inflammation in mice lungs. A qRT-PCR analysis of the levels of CXCL1 and IL-6 mRNA and circFOXO3 in the lung homogenates. B The inflammatory cytokines CXCL1 and IL-6 within the lung homogenates were quantified by ELISAs. C Illustrative micrographs of H&E-stained lung parenchyma samples. D The numbers of all cells, macrophages, and neutrophils in the BALF of mice. E The infiltration by macrophages was analyzed by CD68 staining in the lungs. F Representative photographs of immunostaining for CD11b show the infiltration by neutrophils in the lungs and quantitative analysis of the infiltration by CD11b+ cells (shown on the right). **P < 0.01 vs. negative shRNA control (NC)/Air group or shcircFOXO3/Air group, #P < 0.05 and ##P < 0.01 vs. NC/CS group

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