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Fig. 1 | Respiratory Research

Fig. 1

From: The cellular composition of the lung lining fluid gradually changes from bronchus to alveolus

Fig. 1

The cellular composition of the lung lining fluid gradually changes depending on the location of sampling. A Schematic overview of sample collection sites. Epithelial lining fluid (ELF) samples were bronchoscopically collected using bronchoscopic microsampling (BMS) probes at two different locations, (1) at the main stem bronchus (1–2st generation) and (2) at the large intrasegmental bronchi (3–4th generation). (3) A small bronchial washing (40 mL of saline) is bronchoscopically applied and collected at the small intrasegmental bronchi (4–15th generation) and a (4) broncho-alveolar lavage (150 mL of saline) is bronchoscopically applied and collected at the bronchioles and alveolar compartment. A differential cell count is performed on the collected lung lining fluids and the percentage of B neutrophils, C macrophages and D lymphocytes of the total cell number shown. Data was collected from seven patients, but due to technical issues one central probe sample and two bronchial wash samples were missing. Data is shown as individual data points and mean ± SEM. Statistical significance was tested between samples using a Wilcoxon Signed Rank test, *p < 0.05

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