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Table 3 Prognostic factors for mortality in patients with fibrosing ILD assessed using a Cox proportional hazards model

From: Progressive fibrosing interstitial lung disease: prevalence and clinical outcome

  Unadjusted   Multivariable  
  Hazard Ratio (95% CI) P-value Hazard Ratio (95% CI) P-value
Age 1.069 (1.047–1.091)  < 0.001 1.075 (1.050–1.100)  < 0.001
Male 1.312 (0.901–1.909) 0.157   
BMI 1.025 (0.968–1.086) 0.401   
Ever-smokers 1.137 (0.780–1.657) 0.506   
ILD subtype   0.078
iNSIP 1    
HP 1.874 (0.955–3.678) 0.068   
RA-ILD 1.325 (0.769–2.281) 0.311   
SSc-ILD 0.603 (0.250–1.455) 0.260   
SJS-ILD 1.087 (0.528–2.241) 0.820   
FVC 0.995 (0.984–1.007) 0.416   
DLCO 0.989 (0.978–0.999) 0.031 0.982 (0.971–0.993) 0.001
TLC 0.990 (0.977–1.002) 0.108   
UIP-like pattern 1.642 (1.124–2.399) 0.010 1.458 (0.960–2.212) 0.077
PF-ILD 3.075 (2.107–4.486)  < 0.001 3.053 (2.066–4.512)  < 0.001
Steroid ± IM 0.958 (0.484–1.897) 0.902   
  1. CI confidence interval, PF progressive fibrosing, ILD interstitial lung disease, BMI body mass index, iNSIP idiopathic nonspecific interstitial pneumonia, HP hypersensitivity pneumonitis, RA rheumatoid arthritis, SSc systemic sclerosis, SJS SjÖgren syndrome, FVC forced vital capacity, DLCO diffusing capacity of the lung for carbon monoxide, TLC total lung capacity, UIP usual interstitial pneumonia, IM immunosuppressant