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Table 2 Risk factors for PF-ILD in patients with fibrosing ILD assessed using logistic regression analysis

From: Progressive fibrosing interstitial lung disease: prevalence and clinical outcome

  Unadjusted Multivariable
  Odds Ratio (95% CI) P-value Odds Ratio (95% CI) P-value
Age 1.007 (0.988–1.027) 0.473   
Male 1.213 (0.795–1.850) 0.317   
BMI 1.059 (0.994–1.128) 0.076
Ever-smokers 1.020 (0.669–1.556) 0.926   
ILD subtype   0.004   0.003
 iNSIP 1   1  
 HP 3.530 (1.670–7.462) 0.001 3.763 (1.740–8.138) 0.001
 RA-ILD 1.476 (0.809–2.694) 0.204 1.870 (0.999–3.502) 0.050
 SSc-ILD 1.400 (0.653–3.000) 0.387 1.407 (0.643–3.083) 0.393
 SJS-ILD 0.778 (0.327–1.851) 0.570 0.778 (0.314–1.925) 0.587
FVC 0.985 (0.972–0.997) 0.017 0.982 (0.969–0.996) 0.011
DLCO 0.989 (0.977–1.000) 0.060
TLCa 0.977 (0.963–0.992) 0.003   
UIP-like pattern 0.926 (0.610–1.405) 0.717   
Steroid ± IM 2.278 (0.911–5.695) 0.078
  1. aTLC was excluded in the multivariable analysis due to close correlation with FVC (r = 0.898, P < 0.001)
  2. CI Confidence interval, PF progressive fibrosing, ILD interstitial lung disease, BMI body mass index, iNSIP idiopathic nonspecific interstitial pneumonia, HP hypersensitivity pneumonitis, RA rheumatoid arthritis, SSc systemic sclerosis, SJS SjÖgren syndrome, FVC forced vital capacity, DLCO diffusing capacity of the lung for carbon monoxide, TLC total lung capacity, UIP usual interstitial pneumonia, IM immunosuppressant