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Table 2 Risk factors for PF-ILD in patients with fibrosing ILD assessed using logistic regression analysis

From: Progressive fibrosing interstitial lung disease: prevalence and clinical outcome

 

Unadjusted

Multivariable

 

Odds Ratio (95% CI)

P-value

Odds Ratio (95% CI)

P-value

Age

1.007 (0.988–1.027)

0.473

  

Male

1.213 (0.795–1.850)

0.317

  

BMI

1.059 (0.994–1.128)

0.076

–

–

Ever-smokers

1.020 (0.669–1.556)

0.926

  

ILD subtype

 

0.004

 

0.003

 iNSIP

1

 

1

 

 HP

3.530 (1.670–7.462)

0.001

3.763 (1.740–8.138)

0.001

 RA-ILD

1.476 (0.809–2.694)

0.204

1.870 (0.999–3.502)

0.050

 SSc-ILD

1.400 (0.653–3.000)

0.387

1.407 (0.643–3.083)

0.393

 SJS-ILD

0.778 (0.327–1.851)

0.570

0.778 (0.314–1.925)

0.587

FVC

0.985 (0.972–0.997)

0.017

0.982 (0.969–0.996)

0.011

DLCO

0.989 (0.977–1.000)

0.060

–

–

TLCa

0.977 (0.963–0.992)

0.003

  

UIP-like pattern

0.926 (0.610–1.405)

0.717

  

Steroid ± IM

2.278 (0.911–5.695)

0.078

–

–

  1. aTLC was excluded in the multivariable analysis due to close correlation with FVC (r = 0.898, P < 0.001)
  2. CI Confidence interval, PF progressive fibrosing, ILD interstitial lung disease, BMI body mass index, iNSIP idiopathic nonspecific interstitial pneumonia, HP hypersensitivity pneumonitis, RA rheumatoid arthritis, SSc systemic sclerosis, SJS SjÖgren syndrome, FVC forced vital capacity, DLCO diffusing capacity of the lung for carbon monoxide, TLC total lung capacity, UIP usual interstitial pneumonia, IM immunosuppressant
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Respiratory Research

ISSN: 1465-993X

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