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Table 1 Baseline characteristics of COPD group and non-COPD group

From: Developmental endothelial locus-1 as a potential biomarker for the incidence of acute exacerbation in patients with chronic obstructive pulmonary disease

Characteristics

COPD

Non-COPD

P-value

 

(n=438)

Total

(n=99)

Ever smoker

(n=46)

Never smoker

(n=53)

 

Age (year)

69.0 ± 7.6

60.5 ± 4.8

61.4 ± 4.9

59.8 ± 4.6

p < 0.001

Sex (male)

394 (90.2%)

56 (56.6%)

44 (95.7%)

12 (22.6%)

p < 0.001

Pack-year

39.0 [24.0;50.0]

0.0

[0.0;17.9]

20.0 [10.0;34.5]

0.0

[0.0; 0.0]

p < 0.001

 Current smoker

107 (24.4%)

8 (8.1%)

  

p < 0.001

 Former smoker

278 (63.5%)

38 (38.4%)

  

p < 0.001

 Never smoker

46 (10.5%)

53 (53.5%)

  

p < 0.001

 Unknown

7 (1.6%)

    

Pre-bronchodilator FEV1(% predicted)

65.0 [51.0;77.0]

102.0 [93.5;111.0]

101.0 [94.0;111.0]

104.0 [93.0;111.0]

p < 0.001

Post-bronchodilator FEV1(% predicted)

68.0

[54.0;80.0]

    

Exacerbation history in past year

57.0 (13.0%)

    

mMRC

1.14±0.82

    

6MWD (meter)

439.0 [370.0;490.8]

    

Lab finding

     

 WBC (×10³/mm³)

6.7

[5.8; 8.3]

4.8

[ 4.0;5.9]

5.2

[ 4.2; 6.0]

4.8 [ 3.9;5.6]

p < 0.001

 Neutrophil (%)

58.4

[51.4;64.2]

55

[48.1;61.6]

57.1

[49.2;60.6]

53.3

[46.8;61.9]

p = 0.008

 Lymphocyte (%)

29.2 [23.4;35.7]

34.3 [28.6;40.4]

33.6 [28.8;38.5]

35.6

[28.6;41.7]

p < 0.001

 CRP (mg/dL)

0.8

[0.4; 1.9]

    

 Fibrinogen (mg/dL)

304.5 [256.5;347.0]

    
  1. Data are presented as mean ± standard deviation, median [interquartile range], or frequency with percentage
  2. mMRC  modified Medical Round Council, 6WMD  six-minute walk distance, WBC  white blood cell, CRP  c-reactive protein