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Table 2 Example of results from a crossover study reporting PD15 on the original and dose doubling (DD) scale [26]

From: The use of the mannitol test as an outcome measure in asthma intervention studies: a review and practical recommendations

Subject

PD15 Results on original scale

Results on DD scale (log2 transformed data)

Placebo (P)

Nedocromil (N)

Ratio N:P

Placebo (P)

Nedocromil (N)

Difference (N-P)

1

188.6

379

2.01

7.559

8.566

1.007

2

36.2

 ≥ 635

17.54

5.178

9.311

4.133

3

76.8

569

7.41

6.263

9.152

2.889

4

 > 635

 > 635

1.00

9.311

9.311

0.000

5

292.4

 > 635

2.17

8.192

9.311

1.119

6

210

 > 635

3.02

7.714

9.311

1.596

7

234.7

 > 635

2.71

7.875

9.311

1.436

8

86.6

328.6

3.79

6.436

8.360

1.924

9

561.3

 > 635

1.13

9.133

9.311

0.178

10

258.8

 > 635

2.45

8.016

9.311

1.295

11

128.4

285.5

2.22

7.005

8.157

1.153

12

76.8

122.8

1.60

6.263

6.940

0.677

13

104.1

122.5

1.18

6.702

6.937

0.235

14

 > 635

 > 635

1.00

9.311

9.311

0.000

15

106.7

 > 635

5.95

6.737

9.311

2.573

16

104.4

170.3

1.63

6.706

7.412

0.706

17

38.7

499.9

12.92

5.274

8.965

3.691

18

223.2

 > 635

2.84

7.802

9.311

1.508

19

124.2

368.9

2.97

6.957

8.527

1.571

20

100.2

172.8

1.72

6.647

7.433

0.786

21

24.8

122.8

4.95

4.632

6.940

2.308

22

142.2

554.5

3.90

7.152

9.115

1.963

23

630.4

 > 635

1.01

9.300

9.311

0.010

24

401.9

 > 635

1.58

8.651

9.311

0.660

Geometric Mean

155.8

409.1

2.63

7.284

8.676

1.392

(95% CI)

(107.0–227.1)

(317.7–526.9)

(2.56–2.69)

(6.741–7.827)

(8.311–9.041)

(1.357–1.428)

  1. Negative tests (PD15 > 635 mg) have a PD15 value of 635 mg imputed for use in calculations
  2. CI confidence interval, DD dose doubling, PD15 provoking dose at 15% drop in FEV1