Fig. 5
From: Reversal of pulmonary arterial hypertension and neointimal formation by kinin B1 receptor blockade
BI113823 inhibits inflammatory cell recruitment and cytokines production in an experimental model of PAH- induced by monocrotaline injection in pneumonectomized rats. A Inflammatory cell count in bronchoalveolar lavage (BAL), B protein content, C TNF-ɑ, and D IL-1β in BAL, E TNF-α in plasma, and F Lung MPO activity of each treatment group. Immunohistochemical analysis for G CD-68 (green color) and proliferating cell nuclear antigen (PCNA) (red color) and their quantification in lung sections from each treatment group. Blue color: DAPI staining of cell nuclei in tissue. All values are mean ± SEM, n = 6–8. #p < 0.05 vs. sham control; †p < 0.05 vs. control (D21); *p < 0.05 vs. vehicle