Fig. 8
From: Gut microbiota dysbiosis contributes to the development of chronic obstructive pulmonary disease
After 20 weeks of exposure, intestinal microbiota from patients with COPD accelerates declines in lung function in recipient mice. a–d After 20 weeks of exposure, the forced expiratory volume in 20 s (FEV20), MMEF (mean mid expiratory flow), minute ventilation volume (MV) and peak expiratory flow (PEF) were significantly lower in the mouse recipients of fecal microbiota from COPD I–II to III–IV patients than from controls. e, f The Cchord (chord compliance, between 0 and 10 cm H20) and FRC (functional residual capacity) were significantly higher in the mouse recipients of fecal microbiota from COPD I–II to III–IV patients than from controls. Significance was determined by ANOVA and p values were corrected using the Bonferroni method. Results are expressed as means ± SD, n = 10 mice. *p < 0.05, **p < 0.01, ***p < 0.001