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Fig. 5 | Respiratory Research

Fig. 5

From: Potentiation of long-acting β2-agonist and glucocorticoid responses in human airway epithelial cells by modulation of intracellular cAMP

Fig. 5

Effect of PDE4 inhibition on LABA/GCS responses in human airway epithelial cells exposed to Poly I:C. An inflammatory stimulus of Poly I:C (1 µg/mL) was used to model a viral challenge in human airway epithelial cells. Combinations of LABA/GCS (budesonide [10 nM]/formoterol [0.01 nM]) and PDE4 inhibitors (roflumilast [1uM], rolipram [10uM], cilomilast [1uM]) were performed with Poly I:C exposure and the cytokines, A IL-6, B IL-8, C CXCL10/IP-10, and D CCL5/RANTES were measured. All data are represented as percentages normalized to positive control stimuli ± SEM. (p < 0.05#, p < 0.0001#### compared with Poly I:C, and p < 0.05* compared with Poly I:C + budesonide/formoterol) n = 5

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