Fig. 4

Effect of ABCC4 inhibition on LABA/GCS responses in human airway epithelial cells exposed to Poly I:C. An inflammatory stimulus of Poly I:C (1 µg/mL) was used to model a viral challenge in human airway epithelial cells. Combinations of LABA/GCS (budesonide [10 nM]/formoterol [0.01 nM]) and ABCC4 inhibitor (Ceefourin-1 [10uM]) were performed with Poly I:C exposure and the cytokines, A IL-6, B IL-8, C CXCL10/IP-10, and D CCL5/RANTES were measured. All data are represented as percentages normalized to positive control stimuli + SEM. (p < 0.05^#, p < 0.01^##, p < 0.001^### compared with Poly I:C, and p < 0.05*, p < 0.01** compared with Poly I:C + budesonide/formoterol). n = 5