Fig. 4

Comparison of lung transcriptome (RNA-seq) and plasma proteome (Somalogics) in advanced IPF. Differential contrasts between IPF and healthy samples were computed using cutoffs of FC ≥ 1.5 and adjusted P value of ≤ 0.1 for both the RNA-seq and Somalogics datasets. Venn diagram represents the intersection of the total signature (a), as well as gene/protein sets commonly upregulated (b) and downregulated (c) in lung and plasma