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Fig. 2 | Respiratory Research

Fig. 2

From: IL-35 subunit EBI3 alleviates bleomycin-induced pulmonary fibrosis via suppressing DNA enrichment of STAT3

Fig. 2

EBI3 deficiency aggravated the symptoms of bleomycin-induced pulmonary fibrosis. A Lung sections of bleomycin treated WT and EBI3 KO mice were stained with Masson Trichrome. Scale bar 200 μm. The serum was collected from these two mice. The protein level of EBI3 was measured by ELISA (n = 9). B Lung function measurements including resistance, elastance and compliance were measured in all four groups using FlexiVent (n = 9). C The lung hydroxyproline was evaluated in bleomycin treated WT and EBI3 KO mice (n = 9). Data are representative of three independent experiments. Data are presented as mean ± SEM. Significance was determined by two-tailed Student’s t test. *P < 0.05 and **P < 0.01

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