Skip to main content

Table 1 Studies characteristics

From: Factors associated with mortality in rheumatoid arthritis-associated interstitial lung disease: a systematic review and meta-analysis

Study Country Study design Enrolment years Inclusion criteria No.RA-ILD/death Follow-up lengths (years)
Wolfe (2007) Multicentre
(US)
Prospective cohort study 2001–2007 RA by 1987 ACR criteria; ILD diagnosed by physician and/or hospital records ICD-9 codes 100/27 Mean 3
Dixon (2010) Multicentre
(UK)
Case–control study 2001–2008 RA diagnosed by a physician; ILD diagnosed by physician and/or hospital records ICD-9 codes 367/84 Median 3.8
Kim (2010) Multicentre
(US)
Case–control study 2001–2008 RA by 1987 ACR criteria;
ILD diagnosis by HRCT
82/8 Median3.9
Koduri (2010) Multicentre
(UK)
Prospective cohort study 1986–1998 RA by 1987 ACR criteria; ILD diagnosed by clinical, chest X-ray and HRCT finding 52/39 Median 10
Tsuchiya (2011) Single-centre (Japan) Retrospective cohort study 1996–2006 RA by 1987 ACR criteria; ILD diagnosed by HRCT finding and/or biopsy 144/71 Median 4.5
Nakamura (2012) Single-centre (Japan) Retrospective cohort study 1989–2009 RA by 1987 ACR criteria;
Surgical lung biopsy-proven ILD
54/9 NA
Solomon (2013) Multicentre
(US)
Retrospective cohort study 1977–1999 RA by 1987 ACR criteria;
Surgical lung biopsy-proven ILD
48/40 Median 3.7
Solomon (2016) Single-centre (US) Retrospective cohort study 1995–2013 RA diagnosed by rheumatologist
ILD diagnosed by HRCT finding
137/54 Mean 4.8
Zamora-Legoff (2016) Single-centre (US) Retrospective cohort study 1998–2014 RA by 1987 ACR criteria
ILD diagnosed by HRCT finding
181/72 Mean 3.1
Hozumi (2013) Single-centre (Japan) Case–control study 1995–2012 RA by 1987 ACR criteria; ILD diagnosed by clinical presentation, pulmonary function tests, HRCT finding and lung biopsy finding 51/12 Mean 8.5
Yang (2017) Single-centre (Republic of Korea) Case–control study 1991–2011 RA by 1987 ACR criteria; ILD diagnosed by clinical features and pulmonary function tests, radiographic finding 77/38 Mean 10
Rojas-Serrano (2017) Single-centre (Mexico) Retrospective cohort study 2004–2015 RA by 1987 ACR or ACR/EULAR 2010 criteria; ILD diagnosed by HRCT finding 78/17 Mean 5.8
Jacob (2018) Multicentre
(UK, Republic of Korea)
Retrospective cohort study 2007–2014
1995–2015
RA by ACR/EULAR 2010 criteria; RA-ILD diagnosed by multidisciplinary team review 245/110 Mean 6.7
Song (2013) Multicentre
(Japan)
Case–control study 1991–2008 RA by 1987 ACR criteria; UIP diagnosed by ATS/ERS consensus classification for IIP and surgical lung biopsy 84/10 Mean 2.75
Kelly (2014) Multicentre
(UK)
Case–control study 1987–2012 RA by ACR/EULAR 2010 criteria
ILD diagnosed by HRCT finding
230/32 Mean 14
San-Koo (2015) Single-centre (Republic of Korea) Retrospective cohort study 2004–2011 RA by 1987 ACR criteria; ILD diagnosed by clinical presentation, pulmonary function testing, and radiographic finding 24/6 NA
Nurmi (2018) Single-centre (Finland) Retrospective cohort study 2000–2014 RA by 1987 ACR criteria;
ILD diagnosed by HRCT finding
60/33 NA
Hyldgaard (2019) Single-centre (Denmark) Retrospective cohort study 2004–2016 RA-ILD diagnosed by physician 102/38 Mean 3.8
Ito (2019) Single-centre (Japan) Retrospective cohort study 2007–2016 RA by ACR/EULAR 2010 criteria;
ILD diagnosed by symptoms and HRCT finding
65/16 Mean 4.7
Yamakawa (2019) Single-centre (Japan) Retrospective cohort study 2012–2017 RA by ACR/EULAR 2010 criteria;
ILD diagnosed by a multidisciplinary team
96/25 Mean 3.7
Kim-2 (2020) Single-centre (Republic of Korea) Case–control study 1995–2015 RA by ACR/EULAR 2010 criteria;
ILD diagnosed by HRCT finding
153/45 Mean 4.5
Li (2020) Single-centre (China) Retrospective cohort study 2008–2017 RA by 1987 ACR or ACR/EULAR 2010 criteria; RA-ILD diagnosed by a work group included experienced rheumatologists and radiologists 278/53 Median 4.25
Wang (2020) Single-centre (China) Case–control study 2016–2019 RA by ACR/EULAR 2010 criteria; ILD diagnosed by clinical presentation, pulmonary function tests, and HRCT findings 45/4 Mean 2.1
  1. ACR American College of Rheumatology; EULAR the European League Against Rheumatism; RA-ILD rheumatoid arthritis-associated interstitial lung disease; HRCT high-resolution CT; ICD International Disease Classification; US United States; UK United Kingdom; NA not available