Fig. 1

Diabetes reduced lung IR-induced mitophagy, and APN restored diabetic lung IR-reduced mitophagy via SIRT1. A OGTT, oral glucose tolerance test (mean ± SD). B IPGTT, intraperitoneal glucose tolerance test (mean ± SD). C Representative blots. D SIRT1 expression in lung tissue (mean ± SD). E Acetylated-FoxO1 expression in lung tissue (mean ± SD). F PINK1 expression in lung tissue (mean ± SD). G Parkin expression in lung tissue (mean ± SD). H LC3-II expression in mitochondria of lung tissue (mean ± SD). I Relative SIRT1 activity in lung tissue (mean ± SD). Ac-FoxO1 acetylated Forkhead box O1, LC3-II microtubule-associated protein 1 light chain 3 beta, PINK1 PTEN-induced kinase. (^aP < 0.05 versus the Con + Sham group, ^bP < 0.05 versus the Con + IR group, ^cP < 0.05 versus the DM + IR group, ^dP < 0.05 versus the DM + IR + A group; n = 8 in each group)