Skip to main content

Table 2 EC50 values of PG-induced ILC2 migration and IL-5 and IL-13 cytokine secretion were calculated and are given as mean ± standard error of the mean (SEM), n = 3

From: Prostaglandin D2 metabolites activate asthmatic patient-derived type 2 innate lymphoid cells and eosinophils via the DP2 receptor

ILC2 migration and cytokine secretion EC50 [nM]

Metabolite

Migration

IL-5 secretion

IL-13 secretion

PGD2

17.4 ± 3.9

139.2 ± 15.5

131.9 ± 10.8

DK-PGD2

14.2 ± 3.4

146.0 ± 18.0

159.2 ± 28.8

∆12-PGD2

19.3 ± 3.2

108.1 ± 11.8

125.2 ± 8.3

15-deoxy-∆12,14-PGD2

21.8 ± 6.3

175.4 ± 26.4

159.1 ± 13.9

9α,11β-PGF2

–a

526.9 ± 12,926.7

788.3 ± 173.7

PGJ2

66.3 ± 7.0

244.4 ± 26.3

321.9 ± 43.8

∆12-PGJ2

91.7 ± 9.2

234.1 ± 30.6

343.2 ± 52.4

15-deoxy-∆12,14-PGJ2

38.1 ± 5.4

185.3 ± 21.5

226.2 ± 35.2

  1. aCurve fit was ambiguous, EC50 value could not be determined