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Fig. 7 | Respiratory Research

Fig. 7

From: Circ_PIP5K1A regulates cisplatin resistance and malignant progression in non-small cell lung cancer cells and xenograft murine model via depending on miR-493-5p/ROCK1 axis

Fig. 7

Circ_PIP5K1A regulated DDP sensitivity to NSCLC in vivo by the expression regulation of miR-493-5p and ROCK1. A, B tumor volume (A) and weight (B) were determined in DDP + lenti-NC, DDP + lenti-circ-PIP5K1A and DDP + sh-circ_PIP5K1A groups. C, D the levels of circ_PIP5K1A and miR-493-5p in tumor tissues were examined by RT-qPCR. E, F ROCK1 mRNA and protein detection was performed via RT-qPCR and Western blot in tumor tissues. G Ki67 and Cleaved caspase3 levels in tumor tissues were analyzed using IHC assay. *P < 0.05, **P < 0.01, ***P < 0.001

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