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Fig. 3 | Respiratory Research

Fig. 3

From: Circ_PIP5K1A regulates cisplatin resistance and malignant progression in non-small cell lung cancer cells and xenograft murine model via depending on miR-493-5p/ROCK1 axis

Fig. 3

Circ_PIP5K1A interacted with miR-493-5p. A the binding sites between circ_PIP5K1A and miR-493-5p were exhibited by starbase. B, C dual-luciferase reporter assay was used to validate the binding between circ_PIP5K1A and miR-493-5p in A549/DDP (B) and H460/DDP (C) cells. D RT-qPCR was applied for the expression detection of miR-493-5p after transfection of si-NC or si-circ_PIP5K1A. E, F the level of miR-493-5p was analyzed using RT-qPCR in DDP-resistant cells (E) and tumor-resistant tissues (F). G Pearson’s correlation coefficient was applied for the analysis of relationship between miR-493-5p and circ_PIP5K1A in tumor-resistant tissues. ***P < 0.001

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Respiratory Research

ISSN: 1465-993X

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