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Fig. 6 | Respiratory Research

Fig. 6

From: Inhibition of HDAC1 alleviates monocrotaline-induced pulmonary arterial remodeling through up-regulation of miR-34a

Fig. 6

MS-275 suppresses pulmonary arterial remodeling, excessive extracellular matrix (ECM) accumulation and the increase of right ventricular systolic pressure (RVSP) and right ventricular hypertrophy index (RVHI) through restoring miR-34a level in monocrotaline (MCT)-induced pulmonary arterial hypertension (PAH) rats. a Hematoxylin and eosin staining of pulmonary arteries (×400 magnification). b Quantitative morphometric analysis of the medial wall thickness of small pulmonary arteries. c Masson’s trichrome staining of pulmonary arteries (×400 magnification). d Changes of RVSP and RVHI in each group, RVHI = RV/(LV + S) (n = 6–8). *P < 0.05 versus control group; #P < 0.05 versus MCT group

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Respiratory Research

ISSN: 1465-993X

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