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Fig. 4 | Respiratory Research

Fig. 4

From: Inhibition of HDAC1 alleviates monocrotaline-induced pulmonary arterial remodeling through up-regulation of miR-34a

Fig. 4

Inhibition of histone deacetylases 1 (HDAC1) restores miR-34a level in monocrotaline (MCT)-induced pulmonary arterial hypertension (PAH) rats and pulmonary arterial smooth muscle cells (PASMCs). a miR-34a level in lung tissues from different groups was determined using quantitative real-time polymerase chain reaction (qRT-PCR) (n = 3). b HDAC activity in lung tissues from different groups was measured with a fluorometric HDAC activity assay kit (n = 3). c Protein level of HDAC1 in PASMCs transfected with HDAC1-specific siRNA or control siRNA was examined using immunoblotting (n = 3). d miR-34a level in PASMCs transfected with HDAC1-specific siRNA or control siRNA was tested using qRT-PCR (n = 3). *P < 0.05 versus control group; #P < 0.05 versus MCT group

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