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Fig. 1 | Respiratory Research

Fig. 1

From: Inhibition of HDAC1 alleviates monocrotaline-induced pulmonary arterial remodeling through up-regulation of miR-34a

Fig. 1

Protocol for generation of rat pulmonary arterial hypertension (PAH) and reagent intervention models. The rat PAH model was induced by intraperitoneally injection of monocrotaline (MCT) (60 mg/kg) on day 1. MS-275 (3 mg/kg) was administrated to rats by intraperitoneally injection every other day for 28 days after MCT injection. miR-34a agomiR (25 μM) was given to rats via tail vein injection on days 1, 7, 14, 21 and 28 respectively after MCT injection

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Respiratory Research

ISSN: 1465-993X

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