Smoking induces sex-specific changes in the small airway proteome

Kokelj, Spela; Östling, Jörgen; Georgi, Benjamin; Fromell, Karin; Ekdahl, Kristina Nilsson; Olsson, Henric K.; Olin, Anna-Carin

doi:10.1186/s12931-021-01825-6

Respiratory Research

Table 3 Comparison of the most prominent proteins for separating current smokers from never smokers

From: Smoking induces sex-specific changes in the small airway proteome

Protein	Current smokers vs never smokers
	Women			Men
	p-value	q-value	log₂(fold change)	p-value	q-value	log₂(fold change)
Fibrinogen	1.59E−04	0.025	− 0.94
Follistatin-related protein 3	1.64E−03	0.067	− 0.64	5.54E−05	0.011	− 0.58
Beta-2-microglobulin	4.72E−03	0.072	− 0.92
Complement factor H	4.77E−03	0.072	− 0.81
Complement C2	3.39E−03	0.072	− 0.76
Complement C3b, inactivated	4.75E−03	0.072	− 0.71
Vitamin K-dependent protein S	4.62E−03	0.072	− 0.69	2.47E−03	0.100	− 0.51
Complement C3	5.31E−03	0.072	− 0.64
Inhibin beta A chain	2.65E−03	0.072	− 0.62	1.53E−03	0.078	− 0.54
Complement component C9	5.31E−03	0.072	− 0.54
C3a anaphylatoxin des Arginine	6.54E−03	0.079	− 0.69
Antithrombin-III	8.35E−03	0.094	− 0.58
Complement decay-accelerating factor	0.016	0.097	− 0.67	4.20E−03	0.132	− 0.62
Adiponectin	0.016	0.097	− 0.67
Complement C5	9.61E−03	0.097	− 0.64
Hepatocyte growth factor-like protein	0.013	0.097	− 0.64
Contactin-1	0.018	0.097	− 0.64
Alpha-1-antichymotrypsin complex	0.015	0.097	− 0.62
Complement factor D	0.017	0.097	− 0.60	0.010	0.216	− 0.60
EGF-containing fibulin-like extracellular matrix protein 1	0.014	0.097	− 0.60
Fetuin-B	0.013	0.097	− 0.56
Protein FAM3B	0.016	0.097	− 0.56
Extracellular matrix protein 1	0.014	0.097	− 0.54
Complement component C6	0.013	0.097	− 0.54
Testican-2	0.016	0.097	− 0.54	8.08E−04	0.055	− 0.51
Immunoglobulin A	0.020	0.105	− 0.51	0.024	0.286	− 0.64
Complement C4	0.024	0.116	− 0.76
Macrophage mannose receptor 1	0.024	0.116	− 0.69
Complement component C7	0.023	0.116	− 0.54
Lumican	0.023	0.116	− 0.51
Extracellular superoxide dismutase [Cu–Zn]	0.025	0.118	− 0.62
Pigment epithelium-derived factor	0.027	0.120	− 0.56
Plasma kallikrein	0.036	0.134	− 0.56
Advanced glycosylation end product-specific receptor, soluble	0.046	0.164	− 0.54	2.90E−04	0.029	− 0.74
Complement C4b	0.051	0.177	− 0.60
Follistatin-related protein 1	0.073	0.198	− 0.56
Immunoglobulin G	0.075	0.198	− 0.51
Heat shock protein HSP 90-beta	2.50E−04	0.025	0.99
Heat shock protein HSP 90-alpha/beta	1.18E−03	0.060	0.75
14–3-3 protein zeta/delta	5.30E−03	0.072	0.57
Translationally-controlled tumor protein	3.23E−03	0.072	0.58	0.022	0.286	0.58
Tropomyosin alpha-4 chain	6.61E−03	0.079	0.82
14–3-3 protein beta/alpha	9.75E−03	0.097	0.52
6-phosphogluconate dehydrogenase, decarboxylating	0.010	0.097	0.55	0.063	0.397	0.64
Heat shock cognate 71 kDa protein	0.011	0.097	0.84
Ferritin	0.016	0.097	1.05
Alpha-enolase	0.026	0.118	0.55
Fatty acid-binding protein, heart	0.032	0.130	0.54	0.098	0.463	0.55
Protein S100-A6	0.033	0.130	0.57
Cofilin-1				0.020	0.286	0.51
C-X-C motif chemokine 16				0.047	0.370	0.54

Proteins shown were selected based on the volcano plots shown in Fig. 3a and b

Back to article page

ISSN: 1465-993X

Contact us

General enquiries: journalsubmissions@springernature.com