Fig. 2

Influence of pioglitazone administration 42 h after induction of pneumonia. Mice were infected with K. pneumoniae via the airways and treated with pioglitazone (10 mg/g) or vehicle at 6 and 30 h after infection (n = 8 per group); effects were assessed 42 h post-infection. A Bacterial loads in lungs, blood, spleen and liver. B TNF, IL-6, IL-1β, CXCL2 and MPO levels in lung homogenates. Graphs show median and every dot represents one individual mouse. P values were calculated using Mann–Whitney U tests. *P < 0.05, **P < 0.01, ***P < 0.001, ns not significant