Skip to main content

Table 3 Association of MBL, ficolin-2, and immunoglobulin concentrations and deficiencies with the primary and secondary endpoints

From: Association of mannose-binding lectin, ficolin-2 and immunoglobulin concentrations with future exacerbations in patients with chronic obstructive pulmonary disease: secondary analysis of the randomized controlled REDUCE trial

 

Number of patients

Re-exacerbation within 180 days

Admission to ICU

 > 1 exacerbation within 180 days

Yes

No

Yes

No

Yes

No

Total

N = 178

N = 65

N = 113

N = 24

N = 154

N = 22

N = 156

MBL, median (IQR), ng/mL

1286 (2427)

1854 (2390)

1141 (2462)*

2210 (2702)

1232 (2353)*

1539 (2231)

1344 (2471)

MBL < 500 ng/mL, n (%)

56 (31)

16 (25)

40 (35)

5 (21)

51 (33)

4 (18)

52 (33)

Ficolin-2, median (IQR), ng/mL

5338 (2949)

5705 (3330)

5245 (3004)

5275 (2523)

5325 (3030)

5226 (3086)

5339 (2890)

Ficolin-2 < 3985 ng/mL, n (%)

45 (25)

14 (22)

31 (27)

6 (25)

39 (25)

6 (27)

39 (25)

IgG total, median (IQR), g/L

9.2 (3.8)

8.8 (4.5)

9.4 (2.9)

8.7 (4.7)

9.3 (3.7)

7.8 (3.1)

9.5 (3.7)*

IgG deficiency, n (%)

49 (28)

22 (34)

27 (24)

9 (38)

40 (26)

10 (45)

39 (25)

IgG1, median (IQR), g/L

5.5 (2.7)

5.1 (3.4)

5.7 (2.2)

5.2 (3.0)

5.5 (2.7)

4.6 (1.3)

5.6 (2.7)*

IgG1 deficiency, n (%)

65 (37)

29 (45)

36 (32)

12 (50)

53 (34)

14 (64)

51 (33)*

IgG2, median (IQR), g/L

2.8 (1.7)

2.7 (1.9)

2.8 (1.6)

2.5 (1.5)

2.8 ( 1.7)

2.1 (1.8)

2.8 (1.6)

IgG2 deficiency, n (%)

16 (9)

9 (14)

7 (6)

1 (4)

15 (10)

4 (18)

12 (8)

IgG3, median (IQR), g/L

0.45 (0.35)

0.44 (0.4)

0.46 (0.32)

0.44 (0.35)

0.45 (0.35)

0.34 (0.24)

0.46 (0.35)*

IgG3 deficiency, n (%)

20 (11)

11 (17)

9 (8)

5 (21)

15 (10)

3 (14)

17 (11)

IgG4, median (IQR), g/L

0.34 (0.49)

0.27 (0.37)

0.39 (0.57)

0.41 (0.39)

0.33 (0.58)

0.18 (0.23)

0.38 (0.56)

IgG4 deficiency, n (%)

23 (13)

10 (15)

13 (12)

3 (12)

20 (13)

2 (9)

21 (13)

IgA total, median (IQR), g/L

2.5 (1.5)

2.6 (1.4)

2.4 (1.5)

2.4 (1.2)

2.5 (1.6)

2.3 (1.1)

2.5 (1.6)

IgA deficiency, n (%)

7 (4)

3 (5)

4 (4)

1 (4)

6 (4)

2 (9)

5 (3)

IgA1, median (IQR), g/L

2.03(1.23)

2.11 (1.37)

1.90 (1.24)

2.1 (1.1)

2.0 (1.3)

1.9 (0.9)

2.1 (1.4)

IgA1 deficiency, n (%)

7 (4)

3 (5)

4 (4)

1 (4)

6 (4)

2 (9)

5 (3)

IgA2, median (IQR), g/L

0.53 (0.44)

0.54 (0.43)

0.52 (0.42)

0.53 (0.45)

0.54 (0.41)

0.45 (0.22)

0.54 (0.45)

  1. *Significant (< 0.05) p-values derived from Mann–Whitney U-test or Chi-square test, where appropriate
  2. MBL mannose-binding lectin, IQR interquartile range, ICU intensive care unit, Ig immunoglobulin