Table 3 Final multivariable logistic regression models for six organ involvements showing associations with occupational and environmental exposures in patients with sarcoidosis
Exposure | Pulmonary only (n = 164) | Liver involvement (n = 23) | Splenic involvement (n = 37) | Cardiac involvement (n = 17) | Eye involvement (n = 29) | Skin granulomas (n = 23) | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
OR | 95% CI | p | OR | 95% CI | p | OR | 95% CI | p | OR | 95% CI | p | OR | 95% CI | p | OR | 95% CI | p | |
Reactive chemicals (n = 26) | – | – | – | 5.08* | 1.28–19.2 | 0.016 | – | – | ||||||||||
Inorganic dust (n = 74) | 2.11* | 1.11–4.17 | 0.026 | – | – | 0.21* | 0.04–0.76 | 0.029 | – | – | ||||||||
Organic dust (n = 63) | 1.86 | 0.95–3.82 | 0.079 | – | – | 0.22 | 0.03–0.91 | 0.066 | – | – | ||||||||
Contact with livestock (n = 15) | 0.23* | 0.07–0.71 | 0.012 | 3.68* | 0.91–12.7 | 0.047 | 4.94* | 1.46–16.1 | 0.008 | 9.86* | 1.95–49.0 | 0.004 | 0.00 | > 0.99 | – | |||
Close human contact (n = 31) | – | 4.33* | 1.57–11.3 | 0.003 | 3.78* | 1.47–9.46 | 0.005 | – | – | – | ||||||||
Administrative work only (n = 42) | – | – | 2.52* | 0.99–6.16 | 0.046 | – | – | – | ||||||||||
Active smoker (n = 43) | – | – | – | – | 3.26* | 1.33–7.79 | 0.008 | 2.50 | 0.89–6.54 | 0.069 | ||||||||