The impact of fluid status and decremental PEEP strategy on cardiac function and lung and kidney damage in mild-moderate experimental acute respiratory distress syndrome

Table 2 Arterial blood gases at ZEEP (BASELINE), after PEEP = 9 cmH₂O and at FINAL

	FLUIDS	PEEP	ZEEP	PEEP 9	FINAL
pHa	NORMO	FAST	7.24 ± 0.09	7.19 ± 0.23	7.16 ± 0.09
	HIGH	FAST	7.25 ± 0.04	7.18 ± 0.08	7.17 ± 0.07
	NORMO	SLOW	7.23 ± 0.05	7.21 ± 0.20	7.14 ± 0.08
	HIGH	SLOW	7.23 ± 0.06	7.13 ± 0.10	7.15 ± 0.08
PaO₂/FiO₂ (mmHg)	NORMO	FAST	241 ± 114	435 ± 40*	390 ± 51*
	HIGH	FAST	232 ± 90	365 ± 55*	425 ± 35*
	NORMO	SLOW	222 ± 70	430 ± 25*	396 ± 31*
	HIGH	SLOW	282 ± 89	390 ± 95*	360 ± 55*
PaCO₂ (mmHg)	NORMO	FAST	45 ± 6	59 ± 9*	77 ± 22*
	HIGH	FAST	48 ± 5	58 ± 8*	62 ± 17
	NORMO	SLOW	50 ± 6	63 ± 8	65 ± 12
	HIGH	SLOW	51 ± 5	59 ± 10	68 ± 14*
HCO₃⁻ (mEq/L)	NORMO	FAST	20 ± 4	20 ± 5	25 ± 5
	HIGH	FAST	22 ± 6	22 ± 7	23 ± 6
	NORMO	SLOW	21 ± 6	21 ± 6	21 ± 4
	HIGH	SLOW	23 ± 7	21 ± 7	24 ± 7

Values are means ± SD of 7 animals/group. NORMO and HIGH: administration of Ringer lactate at 10 mL/kg/h and 30 mL/kg/h, respectively. FAST: abrupt PEEP decrease from 9 to 3 cmH₂O. SLOW: gradual PEEP decrease (0.2 cmH₂O/min) from 9 to 3 cmH₂O
pHa arterial pH, PaO₂/FiO₂ ratio of partial pressure of oxygen in arterial blood to fraction of inspired oxygen, PaCO₂ partial pressure of carbon dioxide, HCO₃⁻ bicarbonate
*Significantly different from BASELINE (p < 0.05)

ISSN: 1465-993X