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Fig. 3 | Respiratory Research

Fig. 3

From: The impact of fluid status and decremental PEEP strategy on cardiac function and lung and kidney damage in mild-moderate experimental acute respiratory distress syndrome

Fig. 3

Expression of biomarkers associated with inflammation [interleukin (IL)-6], tight junctions [zonula occludens (ZO)-1], epithelial cell damage [club cell protein (CC)-16], extracellular matrix remodeling (versican, syndecan-1), and endothelial cell damage [(vascular endothelial growth factor (VEGF)]. Relative gene expression was calculated as a ratio of the average gene expression levels compared with the reference gene (acidic ribosomal phosphoprotein P0, 36B4) and expressed as fold change relative to non-ventilated animals (NV). Boxes show the interquartile (25–75%) range, whiskers encompass the range (minimum to maximum), and horizontal lines represent median values of 7 animals/group. Rats received a standard (10 mL/kg/h, NORMO) or high (30 mL/kg/h, HIGH) volume of Ringer’s lactate. FAST: abrupt PEEP decrease from 9 to 3 cmH2O; SLOW: gradual PEEP decrease (0.2 cmH2O/min) from 9 to 3 cmH2O

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Respiratory Research

ISSN: 1465-993X

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