Skip to main content
Fig. 2 | Respiratory Research

Fig. 2

From: The impact of fluid status and decremental PEEP strategy on cardiac function and lung and kidney damage in mild-moderate experimental acute respiratory distress syndrome

Fig. 2

A representative photomicrographs (light microscopy) of lung parenchyma stained with hematoxylin–eosin. Photomicrographs are representative of data obtained from lung sections of 7 animals (original magnification, × 400). Bars = 100 μm. Note the presence of interstitial edema (asterisk), lung overdistension (double arrows), and alveolar-capillary damage (presence of neutrophils and erythrocytes in the alveolar septa) (two arrows). B diffuse alveolar damage (DAD) score; scores arithmetically averaged from two independent investigators representing injury from interstitial edema, overdistension, alveolar collapse, septal inflammation, and alveolar hemorrhage. Boxes show the interquartile (25–75%) range, whiskers encompass the range (minimum to maximum), and horizontal lines represent median values of seven animals/group. Rats received a standard (10 mL/kg/h, NORMO) or high (30 mL/kg/h, HIGH) volume of Ringer’s lactate. FAST: abrupt PEEP decrease from 9 to 3 cmH2O; SLOW: gradual PEEP decrease (0.2 cmH2O/min) from 9 to 3 cmH2O

Back to article page

Respiratory Research

ISSN: 1465-993X

Contact us