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Fig. 2 | Respiratory Research

Fig. 2

From: Turnover of type I and III collagen predicts progression of idiopathic pulmonary fibrosis

Fig. 2

Longitudinal biomarker levels are elevated in progressive IPF patients.Serum levels of C1M (A), PRO-C3 (B) and C3M (C) are shown at baseline, six months and 12 months for stable (dark blue) and progressive (grey) patients with IPF. Disease progression was defined as ≥ 5% decline in FVC and/or ≥ 10% decline in DLco or all-cause mortality within 12 months. Data are presented as mean and 95% CI (error bars) adjusted for age and sex. The number of evaluable samples available for analysis at each time point is provided in the graph. The P-values for the interaction between visit and progression status for C1M (P = 0.63), PRO-C3 (P = 0.46) and for C3M (P = 0.86). Significant differences between progressive and stable patients over one year are shown as ** (P < 0.01) and * (P < 0.05)

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