Genetic evidence for a causative effect of airflow obstruction on left ventricular filling: a Mendelian randomisation study

Table 2 Results of 19 SNPs that shared the direction of the overall Mendelian randomisation (MR) effect and were significant in single SNP MR analyses of FEV1/FVC on LVEDV

SNP	Minor allele	MAF (1000 Genomes Phase 3)	MAF (Exposure)	Relation to nearest gene	Single SNP MR analyses						Percentage decrease of overall effect in leave-one-out MR-IVW
					Odds ratio	95% confidence interval		Estimate	Standard error	P-value
						Lower	Upper
rs995758	T	0.30	0.40	Downstream, HHIP	1.3	1.1	1.54	0.27	0.09	0.002	16.7
rs2070600	T	0.07	0.06	Missense, AGER	1.24	1.05	1.46	0.22	0.08	0.01	13.4
rs7733410	A	0.45	0.44	Intron, HTR4	1.33	1.05	1.67	0.28	0.12	0.016	9.3
rs1192415	G	0.22	0.19	Upstream, TGFBR3	1.62	1.16	2.27	0.48	0.17	0.005	8.1
rs113315602	C	0.03	0.09	Downstream, HLA-DRB1	1.37	1.05	1.79	0.32	0.14	0.02	7.9
rs840467	T	0.12	0.19	Downstream, LOX	2.39	1.46	3.91	0.87	0.25	< 0.001	7
rs281861363	T	0.04	0.09	Intron, HLA-DQB1	1.36	1.02	1.82	0.31	0.15	0.037	6.5
rs13332450	C	0.23	0.93	Downstream, FAM65A	2.35	1.34	4.13	0.86	0.29	0.003	5.3
rs10059996	G	0.40	0.36	Upstream, FGF18	1.43	1.01	2.03	0.36	0.18	0.045	5.3
rs4353138	T	0.37	0.46	Downstream, IPP	4.91	2.23	10.84	1.59	0.4	< 0.001	5.1
rs9874847	T	0.17	0.14	Intron, WNT7A	2.48	1.37	4.5	0.91	0.3	0.003	5
rs7118465	C	0.43	0.32	Intron, NTM	1.88	1.14	3.09	0.63	0.25	0.012	4.9
rs201191	A	0.40	0.49	Intron, AL445623.2 (lncRNA)	1.82	1.08	3.06	0.6	0.27	0.025	4.2
rs10460533	A	0.23	0.29	Intron, EML4	2.18	1.19	3.98	0.78	0.31	0.011	4.2
rs12134019	T	0.05	0.14	Intron, HMCN1	1.87	1.08	3.21	0.62	0.28	0.024	4
rs2285261	A	0.49	0.38	Intron, MICU3	2.09	1.12	3.89	0.74	0.32	0.021	3.7
rs6433079	C	0.34	0.76	Intron, CERS6	1.91	1.04	3.5	0.65	0.31	0.036	3.4
rs4721457	C	0.11	0.15	Upstream, AC006041.1 (lncRNA)	2.06	1.06	4.01	0.72	0.34	0.034	3.1
rs62283793	T	0.07	0.05	Intron, FNDC3B	2.26	1.06	4.84	0.82	0.39	0.035	2.8

ISSN: 1465-993X