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Table 3 Estimates of MID for UCSDSOBQ by anchor-based and distribution-based methods

From: Validation and minimum important difference of the UCSD Shortness of Breath Questionnaire in fibrotic interstitial lung disease

Ancho-based MID estimates
Anchor Linear regression equation MID for anchor MID for UCSDSOBQ
SGRQ UCSD = -5.524 + 1.047*SGRQ 5–8 5.2–8.4
EQ-5D-5L UCSD = 115.2 – 100.2*EQ-5D-5L 0.054 5.4
EQ-VAS UCSD = 94.13 – 0.84*EQ-VAS 5 4.2
FVC% UCSD = 77.24 – 0.54*FVC% 2–6% 1.1–3.2
DLCO% UCSD = 65.77 – 0.54*DLCO% 11% 5.9
6MWD UCSD = 77.41 – 0.097*6MWD 20.7–35.4 m 2.0–3.4
Distribution-based MID estimates
 Standard error measurement approach 4.5
  1. 6MWD 6-min walk distance, DLCO diffusing capacity of the lung for carbon monoxide, EQ-5D-5L European Quality of Life 5 Dimensions 5 Levels questionnaire, EQ-VAS European Quality of Life visual analogue scale, FVC forced vital capacity, MID minimum important difference, SGRQ St. George’s Respiratory Questionnaire, UCSDSOBQ University of California, San Diego Shortness of Breath Questionnaire