Validation and minimum important difference of the UCSD Shortness of Breath Questionnaire in fibrotic interstitial lung disease

Table 2 Change in anchors across tertiles of change in UCSDSOBQ over 6 months

Tertiles of change in UCSDSOBQ	Number of patients	Tertile 1 (decrease in UCSDSOBQ)	Tertile 2 (minimal change)	Tertile 3 (increase in UCSDSOBQ)
mean ∆UCSDSOBQ	468	− 11.8 ± 9.4	2.3 ± 2.9	20.18 ± 13.71
∆ reported in SGRQ		− 4.7 ± 10.4	0.7 ± 8.4	7.5 ± 11.0
mean ∆UCSDSOBQ	740	− 12.6 ± 10.8	2.2 ± 2.9	20.7 ± 13.4
∆ reported in EQ-5D-5L		0.037 ± 0.130	− 0.006 ± 0.102	− 0.084 ± 0.167
mean ∆UCSDSOBQ	760	− 12.8 ± 11.3	2.2 ± 2.9	20.5 ± 13.4
∆ reported in EQ-VAS		4.1 ± 15.3	0.2 ± 13.4	− 7.5 ± 18.9
mean ∆UCSDSOBQ	555	− 12.4 ± 11.1	2.0 ± 2.9	19.0 ± 12.0
∆ reported in FVC		1.4 ± 5.9	− 1.0 ± 6.5	− 1.8 ± 6.5
mean ∆UCSDSOBQ	442	− 12.4 ± 11.1	2.2 ± 3.0	18.0 ± 10.3
∆ reported in DLCO		0.4 ± 7.2	− 2.0 ± 9.2	− 2.0 ± 8.2
mean ∆UCSDSOBQ	245	− 13.3 ± 10.9	1.9 ± 2.7	18.7 ± 11.8
∆ reported in 6MWD		− 2.8 ± 54.9	− 3.9 ± 91.3	− 30.3 ± 101.9

Data shown in bold font are the change in each anchor across tertiles of change in UCSDSOBQ. Data shown in regular font are the mean change in UCSDSOBQ for each tertile of change, based on the patients with available data for that anchor
6MWD 6-min walk distance, DLCO diffusing capacity of the lung for carbon monoxide, EQ-5D-5L European Quality of Life 5 Dimensions 5 Levels questionnaire, EQ-VAS European Quality of Life visual analogue scale, FVC forced vital capacity, SGRQ St. George’s Respiratory Questionnaire, UCSDSOBQ University of California, San Diego Shortness of Breath Questionnaire

ISSN: 1465-993X