Fig. 1

Effect of maintenance inhaled corticosteroid (ICS) and sex on ACE2 expression in the large airway epithelium (LAE). A, B All nonsmoker asthmatics (n = 57) vs healthy nonsmoker controls (n = 29). C, D Nonsmoker asthmatics on maintenance ICS (ICS⁺, n = 19) vs nonsmoker asthmatics not on ICS (ICS⁻, n = 38). A All asthmatics vs controls, by phenotype (ANCOVA, with age as a co-variant). B All asthmatics vs controls, by phenotype and sex (ANOVA). C Asthmatics ICS⁺ vs asthmatics ICS⁻, by phenotype (ANCOVA, with sex as a co-variant). D Asthmatics ICS⁺ vs asthmatics ICS⁻, by phenotype and sex (ANOVA). Data is presented as mean ± standard error