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Fig. 6 | Respiratory Research

Fig. 6

From: Mechanism of protective effect of xuan-bai-cheng-qi decoction on LPS-induced acute lung injury based on an integrated network pharmacology and RNA-sequencing approach

Fig. 6

Animal experiment validation. A Histopathological examination was used to verify established acute lung injury (ALI) model and observed treatment effects. Normal, Model, dexamethasone (DEX), and low- and high-dose xuan-bai-cheng-qi decoction (XCD) groups. B TNF-α, IL-6 and IL-1β in BALF were analyzed by ELISA. Each bar represents the mean ± SD. ##P < 0.01 compared with Normal. **P < 0.01 compared with Model. C The results of qRT-PCR were performed to analyze PTEN, PI3K, AKT and MTOR mRNA expression in the lung tissues. D The expressions of phosphorylated-phosphoinositide 3-kinase (p-PI3K), phosphorylated-mammalian target of rapamycin (p-mTOR), hypoxia-inducible factor (HIF)-1α, and vascular epidermal growth factor (VEGF) in lung tissues by western blots (means ± standard deviation, n = 6). ##P < 0.01, compared to control group; **P < 0.01 and *P < 0.05 compared to model group

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Respiratory Research

ISSN: 1465-993X

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