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Fig. 5 | Respiratory Research

Fig. 5

From: Mechanism of protective effect of xuan-bai-cheng-qi decoction on LPS-induced acute lung injury based on an integrated network pharmacology and RNA-sequencing approach

Fig. 5

Screening and analysis of key targets and kernal targets. A Venn diagram between target genes from network pharmacology and differentially expressed genes (DEG) from RNA-sequencing. B Protein–protein interaction (PPI) network constructed using key target genes, the blue dots represent the top 20 targets of degree value in the network, and the green dots represent the rest of the targets with a lower degree value. C The top 20 target genes with degree values above the average value. D Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway-target network constructed using kernel targets and related signaling pathways. Red ellipses indicate overlapping signaling pathways between target-pathway network and kernel target pathway, which include hypoxia-inducible factor (HIF)-1α, phosphoinositide 3-kinase (PI3K)-AKT, mammalian target of rapamycin (mTOR), and vascular epidermal growth factor (VEGF) signaling pathways. E The self-defined geneset containing 57 target genes was significantly enriched in the expression dataset for human lung microvascular endothelial cells (HMVEC) stimulated with or without LPS for 8 h

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Respiratory Research

ISSN: 1465-993X

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