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Table 6 Expression of HSP90 in endobronchial biopsies from patients with different asthma endotypes/phenotypes before and after bronchial thermoplasty

From: Bronchial thermoplasty in asthma: an exploratory histopathological evaluation in distinct asthma endotypes/phenotypes

Asthma endotypes-phenotypes Expression of HSP90 Epithelial cells P Valuea Subepithelial mesenchymal cells P Valuea
Before BT After BT P value* Before BT After BT P value*
eos ≥ 300/μL (N = 6) Absence, n (%)
Mild-Moderate, n (%)
High, n (%)
1 (16.7)
5 (83.3)
0
0
2 (33.3)
4 (66.7)
0.976 0.518 0
2 (33.3)
4 (66.7)
3 (50.0)
2 (33.3)
1 (16.7)
0.039 0.215
eos < 300/μL (N = 16) Absence, n (%)
Mild-Moderate, n (%)
High, n (%)
6 (37.5)
7 (43.8)
3 (18.7)
1 (6.7)
3 (20.0)
11 (73.3)
0.006 2 (12.5)
9 (56.2)
5 (31.3)
8 (53.3)
6 (40.0)
1 (6.7)
0.018
Atopy (N = 15) Absence, n (%)
Mild-Moderate, n (%)
High, n (%)
4 (26.7)
10 (66.7)
1 (6.7)
1 (7.1)
4 (28.6)
9 (64.3)
0.008 0.350 1 (6.7)
7 (46.7)
7 (46.7)
7 (50.0)
5 (35.7)
2 (14.3)
0.008 0.699
No atopy (N = 7) Absence, n (%)
Mild-Moderate, n (%)
High, n (%)
3 (42.8)
2 (28.6)
2 (28.6)
0
1 (14.3)
6 (85.7)
0.570 1 (14.3)
4 (57.1)
2 (28.6)
4 (57.1)
3 (42.9)
0
0.093
Allergy (N = 12) Absence, n (%)
Mild-Moderate, n (%)
High, n (%)
3 (18.2)
8 (72.7)
1 (9.1)
1 (10.0)
3 (20.0)
7 (70.0)
0.025 0.599 1 (9.1)
6 (45.5)
5 (45.5)
5 (40.0)
4 (40.0)
2 (20.0)
0.073 0.350
No allergy (N = 10) Absence, n (%)
Mild-Moderate, n (%)
High, n (%)
4 (40.0)
4 (40.0)
2 (20.0)
0
2 (20.0)
8 (80.0)
0.015 1 (10.0)
5 (50.0)
4 (40.0)
6 (60.0)
4 (40.0)
0
0.013
Smoke exposure (N = 9) Absence, n (%)
Mild-Moderate, n (%)
High, n (%)
2 (22.2)
4 (44.4)
3 (33.3)
1 (11.1)
3 (33.3)
5 (55.6)
0.343 0.059 2 (22.2)
5 (55.6)
2 (22.2)
2 (22.2)
5 (55.6)
2 (22.2)
0.100 0.003
No smoke exposure (N = 13) Absence, n (%)
Mild-Moderate, n (%)
High, n (%)
5 (38.5)
8 (61.5)
0
0
2 (16.7)
10 (83.3)
0.973 0
6 (46.2)
7 (53.8)
9 (75.0)
3 (25.0)
0
0.955
  1. *Comparisons between the groups were performed using a multinomial logistic regression model
  2. aDifference in differences between groups were performed by introducing the interaction of time and group classification in a mixed logistic regression
  3. BT bronchial thermoplasty, HSP heat shock protein