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Table 5 Expression of HSP70 in endobronchial biopsies from patients with different asthma endotypes/phenotypes before and after bronchial thermoplasty

From: Bronchial thermoplasty in asthma: an exploratory histopathological evaluation in distinct asthma endotypes/phenotypes

Asthma endotypes-phenotypes

Expression of HSP70

Epithelial cells

P Valuea

Subepithelial mesenchymal cells

P Valuea

Before BT

After BT

P Value*

Before BT

After BT

P Value*

eos ≥ 300/μL (N = 7)

Absence, n (%)

Mild-Moderate, n (%)

High, n (%)

3 (42.8)

3 (42.8)

1(14.3)

0

2 (28.6)

5 (71.4)

0.047

0.287

0

0

7 (100)

2 (28.6)

4 (57.1)

1 (14.3)

0.973

0.975

eos < 300/μL (N = 16)

Absence, n (%)

Mild-Moderate, n (%)

High, n (%)

5 (31.2)

9 (56.2)

2 (12.5)

1 (6.7)

7 (46.7)

7 (46.7)

0.029

0

6 (37.5)

10 (62.5)

3 (20.0)

7 (46.7)

5 (33.3)

0.063

Atopy (N = 16)

Absence, n (%)

Mild-Moderate, n (%)

High, n (%)

7 (43.7)

7 (43.7)

2 (12.5)

1 (6.7)

6 (40.0)

8 (53.3)

0.011

0.555

0

5 (31.2)

11 (68.8)

3 (20.0)

8 (53.3)

4 (26.7)

0.018

0.446

No atopy (N = 7)

Absence, n (%)

Mild-Moderate, n (%)

High, n (%)

1 (14.3)

5 (71.4)

1 (14.3)

0

3 (42.8)

4 (57.1)

0.117

0

1 (14.3)

6 (85.7)

2 (28.6)

3 (42.8)

2 (28.6)

0.063

Allergy (N = 12)

Absence, n (%)

Mild-Moderate, n (%)

High, n (%)

6 (50.0)

5 (41.7)

1 (8.3)

1 (9.1)

5 (45.5)

5 (45.5)

0.028

0.670

0

3 (25.0)

9 (75.0)

1 (9.1)

6 (54.5)

4 (36.4)

0.073

0.324

No allergy (N = 11)

Absence, n (%)

Mild-Moderate, n (%)

High, n (%)

2 (18.2)

7 (63.6)

2 (18.2)

0

4 (36.4)

7 (63.6)

0.037

0

3 (27.3)

8 (72.7)

4 (36.4)

5 (45.5)

2 (18.1)

0.015

Smoke exposure (N = 9)

Absence, n (%)

Mild-Moderate, n (%)

High, n (%)

1 (11.1)

6 (66.7)

2 (22.2)

1 (11.1)

4 (36.4)

4 (36.4)

0.429

0.045

0

5 (55.6)

4 (44.4)

1 (11.1)

3 (33.3)

5 (55.6)

0.840

0.003

No smoke exposure (N = 14)

Absence, n (%)

Mild-Moderate, n (%)

High, n (%)

7 (50.0)

6 (42.9)

1 (7.1)

0

5 (38.5)

8 (61.5)

0.006

0

1 (7.1)

13 (92.9)

4 (30.8)

8 (61.5)

1 (7.7)

0.020

  1. *Comparisons between the groups were performed using a multinomial logistic regression model
  2. aDifference in differences between groups were performed by introducing the interaction of time and group classification in a mixed logistic regression
  3. BT bronchial thermoplasty, HSP heat shock protein