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Table 5 Expression of HSP70 in endobronchial biopsies from patients with different asthma endotypes/phenotypes before and after bronchial thermoplasty

From: Bronchial thermoplasty in asthma: an exploratory histopathological evaluation in distinct asthma endotypes/phenotypes

Asthma endotypes-phenotypes Expression of HSP70 Epithelial cells P Valuea Subepithelial mesenchymal cells P Valuea
Before BT After BT P Value* Before BT After BT P Value*
eos ≥ 300/μL (N = 7) Absence, n (%)
Mild-Moderate, n (%)
High, n (%)
3 (42.8)
3 (42.8)
1(14.3)
0
2 (28.6)
5 (71.4)
0.047 0.287 0
0
7 (100)
2 (28.6)
4 (57.1)
1 (14.3)
0.973 0.975
eos < 300/μL (N = 16) Absence, n (%)
Mild-Moderate, n (%)
High, n (%)
5 (31.2)
9 (56.2)
2 (12.5)
1 (6.7)
7 (46.7)
7 (46.7)
0.029 0
6 (37.5)
10 (62.5)
3 (20.0)
7 (46.7)
5 (33.3)
0.063
Atopy (N = 16) Absence, n (%)
Mild-Moderate, n (%)
High, n (%)
7 (43.7)
7 (43.7)
2 (12.5)
1 (6.7)
6 (40.0)
8 (53.3)
0.011 0.555 0
5 (31.2)
11 (68.8)
3 (20.0)
8 (53.3)
4 (26.7)
0.018 0.446
No atopy (N = 7) Absence, n (%)
Mild-Moderate, n (%)
High, n (%)
1 (14.3)
5 (71.4)
1 (14.3)
0
3 (42.8)
4 (57.1)
0.117 0
1 (14.3)
6 (85.7)
2 (28.6)
3 (42.8)
2 (28.6)
0.063
Allergy (N = 12) Absence, n (%)
Mild-Moderate, n (%)
High, n (%)
6 (50.0)
5 (41.7)
1 (8.3)
1 (9.1)
5 (45.5)
5 (45.5)
0.028 0.670 0
3 (25.0)
9 (75.0)
1 (9.1)
6 (54.5)
4 (36.4)
0.073 0.324
No allergy (N = 11) Absence, n (%)
Mild-Moderate, n (%)
High, n (%)
2 (18.2)
7 (63.6)
2 (18.2)
0
4 (36.4)
7 (63.6)
0.037 0
3 (27.3)
8 (72.7)
4 (36.4)
5 (45.5)
2 (18.1)
0.015
Smoke exposure (N = 9) Absence, n (%)
Mild-Moderate, n (%)
High, n (%)
1 (11.1)
6 (66.7)
2 (22.2)
1 (11.1)
4 (36.4)
4 (36.4)
0.429 0.045 0
5 (55.6)
4 (44.4)
1 (11.1)
3 (33.3)
5 (55.6)
0.840 0.003
No smoke exposure (N = 14) Absence, n (%)
Mild-Moderate, n (%)
High, n (%)
7 (50.0)
6 (42.9)
1 (7.1)
0
5 (38.5)
8 (61.5)
0.006 0
1 (7.1)
13 (92.9)
4 (30.8)
8 (61.5)
1 (7.7)
0.020
  1. *Comparisons between the groups were performed using a multinomial logistic regression model
  2. aDifference in differences between groups were performed by introducing the interaction of time and group classification in a mixed logistic regression
  3. BT bronchial thermoplasty, HSP heat shock protein