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Table 3 Expression of Ki67 in endobronchial biopsies from patients with different asthma endotypes/phenotypes before and after bronchial thermoplasty

From: Bronchial thermoplasty in asthma: an exploratory histopathological evaluation in distinct asthma endotypes/phenotypes

Asthma endotypes/phenotypes Expression of
Ki67 (%)#
Epithelial cells Sub-epithelial mesenchymal cells
Before BT After BT P Value* Before BT After BT P Value*
eos ≥ 300/μL (N = 7) Mean ± SD 22.9 ± 17.4 24.1 ± 15.1 0.617 6.1 ± 8.1 4.3 ± 3.9 0.900
Median (IQR) 16.0 (12.0–25.0) 19.8 (11.8–31.8) 2.8 (2.0–7.0) 2.8 (1.3–7.8)
eos < 300/μL (N = 16) Mean ± SD 16.3 ± 9.8 24.0 ± 17.2 0.016 8.4 ± 10.6 4.8 ± 4.6 0.283
Median (IQR) 12.2 (8.8–23.2) 19.8 (11.0–27.3) 6.2 (1.5–10.0) 3.3 (1.8–7.0)
Atopy (N = 16) Mean ± SD 21.0 ± 14.1 24.8 ± 13.2 0.144 8.9 ± 11.4 5.7 ± 4.8 0.540
Median (IQR) 18.8 (9.7–25.3) 22.0 (17.7–28.3) 4.5 (1.8–11.5) 5.3 (1.7–8.3)
No Atopy (N = 7) Mean ± SD 12.1 ± 4.2 22.2 ± 22.6 0.098 4.8 ± 3.2 2.4 ± 1.6 0.173
Median (IQR) 9.7 (8.7–15.3) 14.7 (9.7–25.3) 5.3 (1.3–7.7) 2.0 (0.7–4.0)
Allergy (N = 12) Mean ± SD 19.2 ± 14.6 21.0 ± 12.6 0.243 8.0 ± 6.8 6.0 ± 5.2 0.216
Median (IQR) 15.8 (8.5–24.2) 18.0 (11.8–25.0) 6.8 (2.3–10.0) 4 (1.8–11.0)
No allergy (N = 11) Mean ± SD 17.3 ± 10.6 27.1 ± 19.3 0.028 7.3 ± 12.6 3.4 ± 2.7 0.796
Median (IQR) 13.3 (9.8–25.0) 23.0 (11.0–31.8) 2.8 (1.3–7.8) 2.0 (1.3–6.3)
Smoke exposure (N = 9) Mean ± SD 19.6 ± 17.6 24.1 ± 19.3 0.234 3.9 ± 4.0 5.1 ± 3.3 0.155
Median (IQR) 9.8 (8.3–25.8) 19.8 (11.0–27.3) 1.8 (1.3–7.0) 4.8 (2.0–7.8)
No smoke exposure (N = 14) Mean ± SD 17.5 ± 8.7 23.9 ± 14.6 0.034 10.1 ± 11.7 4.4 ± 4.9 0.001
Median (IQR) 15.5 (11.0–23.8) 19.8 (14.8–25.3) 6.2 (2.8–12.0) 2.8 (1.3–6.3)
All patients (N = 23) Mean ± SD 18.3 ± 12.6 24.0 ± 16.2 0.014 7.7 ± 9.8 4.7 ± 4.3 0.243
Median (IQR) 15.3 (12.9–23.7) 19.7 (16.8–31.2) 5.3 (3.4–11.9) 3.0 (2.8–6.6)
  1. #Ki67 positive cells per 100 nuclei
  2. *The p value for comparisons between values before and after BT was calculated using ranked mixed linear regression models, where the factor patient was included as a random effect