Table 3 Expression of Ki67 in endobronchial biopsies from patients with different asthma endotypes/phenotypes before and after bronchial thermoplasty

eos ≥ 300/μL (N = 7)

Mean ± SD

22.9 ± 17.4

24.1 ± 15.1

6.1 ± 8.1

4.3 ± 3.9

Median (IQR)

16.0 (12.0–25.0)

19.8 (11.8–31.8)

2.8 (2.0–7.0)

2.8 (1.3–7.8)

eos < 300/μL (N = 16)

Mean ± SD

16.3 ± 9.8

24.0 ± 17.2

8.4 ± 10.6

4.8 ± 4.6

Median (IQR)

12.2 (8.8–23.2)

19.8 (11.0–27.3)

6.2 (1.5–10.0)

3.3 (1.8–7.0)

Atopy (N = 16)

Mean ± SD

21.0 ± 14.1

24.8 ± 13.2

8.9 ± 11.4

5.7 ± 4.8

Median (IQR)

18.8 (9.7–25.3)

22.0 (17.7–28.3)

4.5 (1.8–11.5)

5.3 (1.7–8.3)

No Atopy (N = 7)

Mean ± SD

12.1 ± 4.2

22.2 ± 22.6

4.8 ± 3.2

2.4 ± 1.6

Median (IQR)

9.7 (8.7–15.3)

14.7 (9.7–25.3)

5.3 (1.3–7.7)

2.0 (0.7–4.0)

Allergy (N = 12)

Mean ± SD

19.2 ± 14.6

21.0 ± 12.6

8.0 ± 6.8

6.0 ± 5.2

Median (IQR)

15.8 (8.5–24.2)

18.0 (11.8–25.0)

6.8 (2.3–10.0)

4 (1.8–11.0)

No allergy (N = 11)

Mean ± SD

17.3 ± 10.6

27.1 ± 19.3

7.3 ± 12.6

3.4 ± 2.7

Median (IQR)

13.3 (9.8–25.0)

23.0 (11.0–31.8)

2.8 (1.3–7.8)

2.0 (1.3–6.3)

Smoke exposure (N = 9)

Mean ± SD

19.6 ± 17.6

24.1 ± 19.3

3.9 ± 4.0

5.1 ± 3.3

Median (IQR)

9.8 (8.3–25.8)

19.8 (11.0–27.3)

1.8 (1.3–7.0)

4.8 (2.0–7.8)

No smoke exposure (N = 14)

Mean ± SD

17.5 ± 8.7

23.9 ± 14.6

10.1 ± 11.7

4.4 ± 4.9

Median (IQR)

15.5 (11.0–23.8)

19.8 (14.8–25.3)

6.2 (2.8–12.0)

2.8 (1.3–6.3)

All patients (N = 23)

Mean ± SD

18.3 ± 12.6

24.0 ± 16.2

7.7 ± 9.8

4.7 ± 4.3

Median (IQR)

15.3 (12.9–23.7)

19.7 (16.8–31.2)

5.3 (3.4–11.9)

3.0 (2.8–6.6)